Two sample MR report
HLA-DRB5_Dendritic Cell (DC) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 28 | -0.2152055 | 0.2747043 | 0.4404659 |
| Weighted median | 28 | -0.0354490 | 0.0227095 | 0.1185285 |
| Inverse variance weighted | 28 | 0.0829183 | 0.0379154 | 0.0287475 |
| Simple mode | 28 | 0.2648858 | 0.0403757 | 0.0000005 |
| Weighted mode | 28 | -0.0655531 | 0.0201775 | 0.0030958 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 480.4140 | 26 | 0 |
| Inverse variance weighted | 502.5958 | 27 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1184809 | 0.1081363 | 0.2832722 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004109 | 3.6e-06 | TRUE | 0.0799423 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
